How to take Esbriet

Taking your dose correctly, from the start and throughout treatment

When starting a new medicine or making a change in dosage, it can take time for your body to adjust. It’s important to find ways to make Esbriet® (pirfenidone) part of your daily routine.

Starting Esbriet

  • Before you start Esbriet, your doctor should do certain blood tests to check how well your liver is working
  • The recommended dosing regimen for Esbriet begins with less pills and builds to the full dose. This is called dose titration. This will happen slowly over the course of 2 weeks
  • This dose titration continues until you reach the recommended maximum daily dose
  • Your doctor may adjust your dose to help alleviate side effects. It is always important to follow your doctor's instructions
  • To help you start and stay on Esbriet, you can download and use the Tracking Your Journey journal >

Esbriet Dosing Schedule

Follow the dosing schedule your doctor gave you. The table below shows the recommended Esbriet dosing schedule. It lists the amount of pills to take at each mealtime, over the first 3 weeks of treatment.

Esbriet dosing schedule
  • The recommended maximum daily dose of Esbriet is 3 pills taken 3 times each day with a meal
  • Doses should be taken at the same times each day: in the morning, afternoon, and evening
  • If you experience side effects, talk with your doctor. He or she may need to reduce your dose or ask you to stop taking it for a short time to help reduce side effects
  • Taking Esbriet with food decreases how quickly Esbriet is absorbed. It also decreases the drug level of Esbriet in the blood.

Make Esbriet part of your daily routine—take it with breakfast, lunch, and dinner

Taking Esbriet with a meal (at breakfast, lunch, and dinner) can help reduce side effects, like nausea and dizziness.

How do I know if I’m having an appropriate meal?

If you are not sure you are eating appropriate meals with each dose of Esbriet, talk to your doctor. Your doctor may also recommend talking to a nutritionist about healthy diets for people with IPF.

Important notes about taking Esbriet

Be sure to remember these points when taking Esbriet. To make it easier, you can write them down and keep them with your medicine.

  • Take Esbriet exactly as your doctor tells you to take it
  • Your doctor may change your dosage of Esbriet as needed
  • If you miss a dose of Esbriet, take it with a meal as soon as you remember
    • Do not take 2 doses at the same time to make up for a missed dose
    • Do not take more than 3 doses (9 pills) in a day
  • If you take too much Esbriet, call your doctor or go to the nearest hospital emergency room right away

Other important things about your Esbriet treatment

  • Once you begin taking Esbriet, you may not “feel” different. This is because Esbriet is meant to slow disease progression. Esbriet does not treat IPF symptoms or undo lung scarring
  • IPF gets worse at different rates in different people. With or without Esbriet, your lung function may continue to decline. Your doctor will do lung function tests to measure how IPF is damaging your lungs over time
Call an Esbriet nurse for more information: 844-693-7274


Information about the possible side effects that people may experience while taking Esbriet.

Information about the possible side effects that people may experience while taking Esbriet.


Managing IPF is not always easy, but there are ways you can help stay focused and strong.

Managing IPF is not always easy, but there are ways you can help stay focused and motivated.