How to take Esbriet

Taking your dose correctly, from the start and throughout treatment

When starting a new medicine or making a change in dosage, it can take time for your body to adjust. It’s important to find ways to make Esbriet® (pirfenidone) part of your daily routine.

Starting Esbriet

  • Before you start Esbriet, your doctor should do certain blood tests to check how your liver is working 
  • When you start Esbriet, your doctor will slowly increase the dose over 2 weeks. This continues until you reach the full daily dose. This will allow your body time to get used to the medicine. (Increasing or decreasing the dose is called titration)
  • Your doctor may adjust your dose to help alleviate side effects. It is always important to follow your doctor's instructions
  • To help you start and stay on Esbriet, you can download and use the Tracking Your Journey journal >

Esbriet dosing schedule

Follow the dosing schedule your doctor gave you. The table below shows the recommended Esbriet dosing schedule for the 267 mg capsules or tablets.

  • The recommended full daily dose of Esbriet is 3 pills (267 mg each, yellow tablets or white capsules) taken 3 times every day with food
    • There is another dosing option with fewer pills per day. To learn more, see the section below
  • Doses should be taken at the same times each day with food: in the morning, afternoon, and evening
    • If you miss a dose of Esbriet, take it with food as soon as you remember
    • Do not take 2 doses at the same time to make up for a missed dose
    • Do not take more than 3 doses in a day
    • If you take too much Esbriet, call your doctor or go to the nearest hospital emergency room right away
  • Taking Esbriet with or at the end of a meal may help reduce certain side effects
  • If you experience side effects, talk with your healthcare provider, who may need to reduce your dose or ask you to stop taking Esbriet for a short time to help reduce side effects

You should always take Esbriet with food. Doing so may help reduce certain side effects including dizziness or nausea. Taking Esbriet with food decreases how quickly Esbriet is absorbed. It also decreases the drug level of Esbriet in the blood.

An option with fewer pills per day

After you are doing well with the 9 pills (267 mg each, yellow tablets or white capsules) of Esbriet a day, you and your doctor may want to talk about moving to a 3 tablet per day option.

  • Each brown tablet has the same amount of medicine as 3 of the 267 mg pills
  • 1 brown tablet is taken 3 times a day with food 
  • After you are doing well on the 9 pills per day, talk with your doctor about whether the 1 brown tablet, 3 times a day, is right for you

Once you are doing well on 9 pills a day, ask your doctor if transitioning to 3 brown tablets is an option for you.

If you have questions about your Esbriet dose, talk to your doctor and see answers to frequently asked questions about Esbriet >

Make Esbriet part of your daily routine—take it with breakfast, lunch, and dinner

Always take Esbriet with food to reduce side effects like nausea and dizziness.

Taking Esbriet with food can slow how quickly it is absorbed by the gut. Talk with your doctor about what foods and how much you should eat with Esbriet.

How do I know if I’m having an appropriate meal?

If you are not sure you are eating appropriate meals with each dose of Esbriet, talk to your doctor. Your doctor may also recommend talking to a nutritionist about healthy diets for people with IPF.

Important notes about taking Esbriet

Be sure to remember these points when taking Esbriet. To make it easier, you can write them down and keep them with your medicine.

  • Take Esbriet exactly as your doctor tells you to take it 
  • Your doctor may change your dosage of Esbriet as needed
  • Always take Esbriet with food to help reduce certain side effects

Other important things about your Esbriet treatment

  • Once you begin taking Esbriet, you may not “feel” different, because Esbriet does not treat the symptoms of IPF and does not reverse the scarring in your lungs
  • IPF worsens at different rates in different people. With or without Esbriet, lung function may continue to decline. Remember, the goal is to slow the decline. Your doctor will conduct lung function tests to measure how IPF is affecting your lungs over time

MANAGING CERTAIN SIDE EFFECTS

Information about the possible side effects that people may experience while taking Esbriet.

Information about the possible side effects that people may experience while taking Esbriet.

TIPS FOR EMOTIONAL WELLBEING

Managing IPF is not always easy, but there are ways you can help stay focused and strong.

Managing IPF is not always easy, but there are ways you can help stay focused and motivated.