Some people may have serious side effects when taking Esbriet, including liver problems, sensitivity to sunlight (including sunlamps) or stomach problems.

Other reported side effects that occurred in 10% or more of people treated with Esbriet in clinical studies included:

• nausea
• rash
• stomach pain
• upper respiratory tract infection
• diarrhea
• fatigue
• headache
• indigestion
• dizziness
• vomiting
• decreased or loss of appetite
• gastroesophageal reflux disease (GERD)
• sinusitis
• sleeplessness
• weight loss
• joint pain

These are not all of the side effects reported with Esbriet. For more information, ask your doctor or pharmacist. See Managing Side Effects to learn more about possible side effects of Esbriet.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.

In clinical studies with Esbriet, some side effects occurred soon after starting treatment, and/or decreased over time:

• Sensitivity to sunlight: The majority of these reactions in clinical studies happened in the first 6 months on treatment. 9% of patients treated with Esbriet experienced sun sensitivity (vs 1% not taking Esbriet)
• Stomach problems: These were most often experienced early in the course of treatment—mostly in the first 3 months—and decreased over time. 2.2% of patients had to stop taking Esbriet because of stomach problems (vs 1% not taking Esbriet)